Diagnostic performance of preoperative CT in differentiating between benign and malignant origin of suspicious gallbladder lesions

PurposeTo determine diagnostic performance of preoperative CT in differentiating between benign and malignant suspicious gallbladder lesions to develop a risk score.MethodAll patients referred January 2007 September 2018 for suspicion cancer (GBC) or incidentally found GBC were retrospectively analyzed. Patients excluded when histopathologic examination was lacking. Two radiologists, blinded histopathology results, independently reviewed images differentiate disease from GBC. Multivariable analysis internal validation used score Model discrimination, calibration, assessed.ResultsIn total, 118 with 39 (33 %) 79 (67 included. Sensitivity diagnosing 90 % (95 confidence interval [CI]: 76–97). Specificity rates 61 CI: 49–72) 59 48–70). Three predictors (irregular lesion aspect, absence fat stranding, locoregional lymphadenopathy) included the ranging -1 4. Adequate (AUC: 0.79, calibration slope: 0.89). In allocated >0 points, model showed higher excluding than radiologists (sensitivity 92 [95 79–98]). Moreover, >3 superior (specificity 99 93–100]).ConclusionsSensitivity differentiation are high, however specificity relatively low. The proposed may facilitate lesions.